Eosinophil granule proteins: what they can tell us about asthma

Since their discovery by Paul Ehrlich in 1879, eosinophils have long been regarded to play a protective role against pathogens, especially during parasite infection.1 Contrary to other granulocytes, eosinophils contain four cationic and acid granule proteins: major basic protein, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN) and eosinophil peroxidase. In response to external stimuli, these granule proteins are released from eosinophils through piecemeal degranulation, exocytosis or cytolysis, along with proinflammatory chemokines and cytokines.1 When activated, eosinophils induce inflammation that leads to tissue injury and subsequent eosinophil-induced diseases. Of them, asthma is a common airway disease in which eosinophils serve as the key inflammatory cells.

Total eosinophil count (TEC) in the blood is currently the most widely used biomarker for phenotyping asthma and initiating biological agents targeting T2 inflammation. Although higher TEC is related to greater treatment response to corticosteroids and T2-targeting biologics, differences in the clinical course...